|
T22814 |
GSA-10
|
|
Hedgehog/Smoothened
|
|
Smoothened (Smo) receptor agonist |
|
T2250 |
DY131
|
DY 131,GSK 9089,DY-131 |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Smo
|
|
DY131 (DY-131) is a novel selective agonist of ERRβ and ERRγ. |
|
T2666 |
Taladegib
|
LY2940680 |
Hedgehog/Smoothened
,
Smo
|
|
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. |
|
T23027 |
MRT-10
|
|
Hedgehog/Smoothened
|
|
MRT-10 is a Smoothened (Smo) receptor antagonist. |
|
T40465 |
SAG dihydrochloride
|
|
Hedgehog/Smoothened
|
|
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It also negates the effects of Cyclopamine inhibition on Smo. |
|
T1779 |
SAG
|
Smoothened Agonist (SAG) HCl,Smoothened Agonist |
Hedgehog/Smoothened
,
Smo
|
|
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway. |
|
T2450 |
SANT-1
|
SANT 1 |
Hedgehog/Smoothened
,
Smo
|
|
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). |
|
T24754 |
Hh-Ag1.5
|
SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened
|
|
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... |
|
T22958 |
M 25
|
|
Others
|
|
M 25 is a Smoothened (Smo) receptor antagonist. |
|
T23307 |
SANT 2
|
SANT-2 |
Others
|
|
SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM). |
|
T71520 |
LEQ-506
|
|
|
|
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand ce... |
|
T38767 |
MRT-83 hydrochloride
|
|
|
|
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in t... |
|
T70693 |
MRT-92 HCl salt
|
|
|
|
MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell prolifera... |
|
T35562 |
Nat-20(S)-yne
|
|
|
|
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which bin... |
|
T83910 |
S1PL-IN-31
|
Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31 |
|
|
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem... |
